The Lewis-Sigler Institute for Integrative Genomics seeks applicants for a Research Specialist I to join the laboratory of Joshua Rabinowitz. Our lab aims to obtain a quantitative understanding of metabolism in eukaryotes ranging from yeasts to mice. More specifically, our bioenergy-oriented goal is to identify and understand metabolic regulation in model and non-model yeasts, with the overarching goal of applying this knowledge to guide rational metabolic engineering design for biofuel production. Discoveries on novel metabolic pathway regulation are made initially by carefully designed isotope-tracing experiments, in which the lab is a world leader, and followed by validation with a few biochemical and genetic approaches.
This will be a one-year term position, with the possibility of renewal contingent upon continued funding and satisfactory performance. Review of applications will begin immediately. The position will start as soon as possible. This position offers a competitive salary plus a comprehensive suite of benefits.
Specific duties include:
Maintain yeast cultivation system and conduct chemostat culture experiments
- Prepare, monitor, collect yeast culture.
- Sample preparation for LC-MS analysis
Maintaining yeast strains
- Receive, revive, and store strains from collaborator labs. Maintain actively used lab strains.
Protein expression and purification
- Heterologous gene expression in yeast
- Protein expression and purification in E. coli
Essential requirements/skills:
- Bachelor’s degree in related field.
- Basic knowledge and skill in biochemistry and molecular biology.
- Strong attention to detail, good habits in note-taking, extra care in data analysis.
- Good time management and experimental planning.
Other relevant (but not required) experience:
- Experience working with yeast culture and yeast genetics.
- Experience working with mass spectrometry.
The final candidate will be required to pass a background check.
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